Dr. Nancy Costigliola

Technical Specialist

Boston, MA
D: 617.345.3352
Overview
Education

Ph.D., Cell Biology and Molecular and Cellular Biophysics, University of North Carolina, Chapel Hill

B.A., Biological Sciences, Cornell University

Dr. Nancy Costigliola is a technical specialist in the Intellectual Property group of the firm’s Boston office. Her work involves patent preparation and prosecution in the field of biotechnology, including molecular biology, cell biology, bioengineering, and biological therapeutics.

Prior to joining Burns & Levinson, Nancy was an imaging research scientist at Vertex Pharmaceuticals. She performed target and compound mechanism-of-action discovery, developed microscopy assays translatable to human assays, and served as a super-resolution imaging subject matter expert across research and development.

Nancy’s post-doctoral fellowship was in the laboratories of Dr. Timothy Mitchison and Dr. Gaudenz Danuser in the Cell and Systems Biology Departments at Harvard Medical School. Nancy’s research focused on determining the characteristics of the vimentin intermediate filament protein essential for mesenchymal migration. She used microscopy and image analysis techniques to define the composition and architecture of the vimentin polymeric network within cells, and found that the fibrous regions of vimentin oriented the force transmission required for cells to migrate as single cells. Her doctoral work at the University of North Carolina, Chapel Hill, in the laboratories of Dr. Kenneth Jacobson and Dr. Timothy Elston, found that the RhoA GTPase regulated contractile oscillations of cortical actin.

Honors & Awards

Honors & Awards

UNC Biophysics Training Award (2006)

American Heart Association Pre-doctoral Fellowship (2008)

Memberships

Memberships

Boston Patent Law Association

Women in the Enterprise of Science & Technology (WEST)

Articles & Publications

Articles & Publications

Costigliola, N., Ding, L., Burckhardt, C.J., Han, S., Gutierrez, E., Groisman, A., Mitchison, T.J.,and Danuser,G. Vimentin fibers orient traction stress. PNAS. 2017 May 16;114(20):5195-5200

Gan., Z., Burckhardt, C.J.,Ding, L, Zaritsky, A., Sitterly, K., Mota, A., Costigliola N., Starker C., Voytas D.,Tytell, J., Danuser, G. Vimentin enhances directed cell migration by stabilizing MT mediated cell polarity. Cell Sys. 2016 Sep 28;3(3):252-63.

Costigliola, N.*, Kapustina, M*., Weinreb, G.E., Monteith, A., Rajfur, Z., Elston, T.C., Jacobson K.. RhoA regulates calcium-independent periodic contractions of the cell cortex. Biophys J. 2010 Aug 9;99(4):1053-63.*These authors contributed equally.

Kapustina, M., Weinreb, G.E., Costigliola, N., Rajfur, Z., Jacobson, K., Elston,T.C.. Mechanical and biochemical modeling of cortical oscillations in spreading cells. Biophys J. 2008 Jun;94(12):4605-20.

Dr. Nancy Costigliola
Practices
  • Patent
  • Intellectual Property
  • Intellectual Property & IP Litigation
Education

Ph.D., Cell Biology and Molecular and Cellular Biophysics, University of North Carolina, Chapel Hill

B.A., Biological Sciences, Cornell University

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